RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice

Emerging evidence highlights epigenetic modulation as a key factor in the pathology of Alzheimer’s disease (AD). Recent studies also suggest that the methyltransferase G9a plays a critical role in regulating learning and memory formation through epigenetic mechanisms. In this context, we present genomic data from a pharmacological intervention using UNC0642, a potent and selective G9a/GLP inhibitor, in SAMP8 mice, a model of Alzheimer’s disease. We have generated novel RNA-seq and miRNA-seq data for three groups: healthy SAMR1, SAMP8 control, and SAMP8 treated with UNC0642 (5 mg/Kg). These data provide insights into miRNA regulation and mRNA modifications in AD under G9a/GLP inhibition, offering valuable information for understanding the molecular changes in AD progression.